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G PROTEIN BETA SUBUNIT-LIKE POLYPEPTIDE
Descriptors Found:
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DeCS
Descriptor
English
:
MTOR Associated Protein, LST8 Homolog
Descriptor
Spanish
:
Homóloga LST8 de la Proteína Asociada al MTOR
Descriptor
Portuguese
:
Homólogo LST8 da Proteína Associada a MTOR
Synonyms
English
:
G protein beta Subunit-like Polypeptide
GBetaL Protein
mLST8 Protein
G protein beta Subunit like Polypeptide
Tree Number:
D05.500.337.250
D08.811.913.696.620.682.700.931.500.250
D12.644.360.024.310
D12.776.157.057.073
D12.776.476.024.389
D12.776.476.925.500.250
Definition
English
:
An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the
MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1
and mTORC2 complex. It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity.
History Note
English
:
2018
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56983
Unique Identifier:
D000076242
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS